How We Lost the Plot on Protein

If nutrition is a popularity contest, one macro has emerged victorious. Driven by cultural pressure and disseminated via the internet, protein hysteria has reached a fever pitch. Per The Economist, ...

Revealing the molecular structures of sugars using galectin-10 protein crystals

A quick, purification-free method was developed by researchers at the Institute of Science Tokyo, to capture the detailed 3D ...

AI-guided analysis assigns amino acid-level roles in protein design

With a newly developed method that compares AI-generated protein sequences with naturally occurring ones, function- and ...
The Scientist

Integral HIV Protein Structure Paves the Way for New Therapeutics

Researchers used cryo-EM to study how the HIV enzyme integrase arranges in 3D to slip its DNA into the host genome and pack ...
EMBO Press

From denaturant to ribosome: rethinking chaperone requirements in cells

DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...
C&EN

Synthetic Multidomain Proteins Containing Unstructured and α-Helical Linkers Reveal a Differential Impact of Molecular Crowding on Catalytic Activity and Conformation

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Molecular ...
C&EN

Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Characterizing high-energy conformations in protein molecules is crucial to delineate ...